A novel systems pharmacology model for herbal medicine injection: a case using reduning injection.

A novel systems pharmacology model for herbal medicine injection: a case using reduning injection. BMC Complement Altern Med. 2014 Nov 4;14(1):430 Authors: Yang H, Zhang W, Huang C, Zhou W, Yao Y, Wang Z, Li Y, Xiao W, Wang Y Abstract BACKGROUND: Compared with the traditional oral administration form, injection administration is basically superior in […]

Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster).

Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster). PLoS One. 2014;9(11):e111572 Authors: Martin AC, Johnston E, Xing C, Hegeman AD Abstract Formerly used world-wide as a popular botanical medicine to reduce anxiety, reports of hepatotoxicity linked to consuming kava extracts in the late 1990s have resulted in global restrictions […]

Immunological effects of ayahuasca in humans.

Immunological effects of ayahuasca in humans. J Psychoactive Drugs. 2014 Nov-Dec;46(5):383-8 Authors: Dos Santos RG Abstract Abstract Ayahuasca is a botanical hallucinogen traditionally used by indigenous groups of the northwest Amazon. In the last decade, the use of ayahuasca has spread from Brazil, Colombia, Ecuador, and Peru to the U.S., Europe, Asia, and Africa. Despite […]

Herbal medicine as inducers of apoptosis in cancer treatment.

Herbal medicine as inducers of apoptosis in cancer treatment. Adv Pharm Bull. 2014 Oct;4(Suppl 1):421-7 Authors: Safarzadeh E, Sandoghchian Shotorbani S, Baradaran B Abstract Cancer is uncontrolled growth of abnormal cells in the body. Nowadays, cancer is considered as a human tragedy and one of the most prevalent diseases in the wide, and its mortality […]

Oral oncoprevention by phytochemicals – a systematic review disclosing the therapeutic dilemma.

Oral oncoprevention by phytochemicals – a systematic review disclosing the therapeutic dilemma. Adv Pharm Bull. 2014 Oct;4(Suppl 1):413-20 Authors: Bhavana SM, Lakshmi CR Abstract The aim of this article is to emphasize and focus on the preclinical and clinical update on phytochemicals and their role in prevention of oral carcinogenesis. Accordingly, the literature search was […]

Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers.

Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers. Ayu. 2014 Jan;35(1):46-9 Authors: Kuchewar VV, Borkar MA, Nisargandha MA Abstract BACKGROUND: It is increasingly being realized that many of today’s diseases are due to “oxidative stress” that results from an imbalance between formation and neutralization of free radicals. Rasayana Chikitsa is a unique […]

Herbal preparation extract for skin after radiotherapy treatment. Part One–Preclinical tests.

Herbal preparation extract for skin after radiotherapy treatment. Part One–Preclinical tests. Acta Pol Pharm. 2014 Sep-Oct;71(5):781-8 Authors: Skalska-Kamińska A, Woźniak A, Paduch R, Kocjan R, Rejdak R Abstract Naran R is a herbal composition made of Plantago lanceolate folium, Malvae arboreae flos, Calendulae flos, Chamomillae inflorescentia, Lamii albi flos to prepare compresses or to wash […]

Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects.

Hippophae rhamnoides oil-in-water (O/W) emulsion improves barrier function in healthy human subjects. Pak J Pharm Sci. 2014 Nov;27(6):1919-22 Authors: Khan BA, Akhtar N Abstract This study aimed to investigate the changes in skin barrier function in human subjects, following long-term topical application of Hippophae rhamnoides oil-in-water (O/W) emulsion whereas effects were measred using non-invasive probes […]

Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases.

Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases. Expert Opin Investig Drugs. 2014 Apr;23(4):523-39 Authors: Liu J, Wang Y, Qiu L, Yu Y, Wang C Abstract INTRODUCTION: Among the notable breakthroughs in the past two decades of research in natural drug discovery is the identification of saponins (saponins in Panax […]

Asparagus, urinary odor, and 1,2-dithiolane-4-carboxylic acid.

Asparagus, urinary odor, and 1,2-dithiolane-4-carboxylic acid. Perspect Biol Med. 2013;56(3):341-51 Authors: Mitchell SC Abstract The derivatives of 1,2-dithiolane are scattered widely throughout the natural world where they are generally exploited for their biocidal properties. One of these, known as asparagusic acid (1,2-dithiolane-4-carboxylic acid), is present in the frequently consumed vegetable, asparagus, and though apparently innocuous […]

Downstream carcinogenesis signaling pathways by green tea polyphenols: a translational perspective of chemoprevention and treatment for cancers.

Downstream carcinogenesis signaling pathways by green tea polyphenols: a translational perspective of chemoprevention and treatment for cancers. Curr Drug Metab. 2014 Jan;15(1):14-22 Authors: Hu G, Zhang L, Rong Y, Ni X, Sun Y Abstract Green tea is one of the most popular beverages around the world. For several decades, numerous epidemiological, preclinical and clinical studies […]

Prodrugs of quercetin and resveratrol: a strategy under development.

Prodrugs of quercetin and resveratrol: a strategy under development. Curr Drug Metab. 2014 Jan;15(1):77-95 Authors: Biasutto L, Zoratti M Abstract The biochemical activities of plant flavonoids and stilbenoids point to many health-related applications, hampered however by a low bioavailability associated with rapid metabolic modification. A possible approach to overcome this obstacle is the development of […]

The metabolism of anthocyanins.

The metabolism of anthocyanins. Curr Drug Metab. 2014 Jan;15(1):3-13 Authors: Hribar U, Ulrih NP Abstract Anthocyanins are the largest group of water-soluble pigments in the plant kingdom. As with other polyphenols, they express antioxidant activity in vivo. Anthocyanins are associated with reduced risk of some several diseases, such as atherosclerosis and diabetes. Their beneficial health […]

Influence of diabetes on the pharmacokinetic behavior of natural polyphenols.

Influence of diabetes on the pharmacokinetic behavior of natural polyphenols. Curr Drug Metab. 2014 Jan;15(1):23-9 Authors: Xiao J, Högger P Abstract The development of food fortified with polyphenols and polyphenol-rich foods represents a novel approach to prevent or attenuate type 2 diabetes. It has been reported that type 2 diabetes may affect the pharmacokinetics of […]

Delivery and application of dietary polyphenols to target organs, tissues and intracellular organelles.

Delivery and application of dietary polyphenols to target organs, tissues and intracellular organelles. Curr Drug Metab. 2014 Jan;15(1):37-47 Authors: Ohara M, Ohyama Y Abstract At present, dietary polyphenols are popular with consumers because regular consumption of polyphenol-rich foods is likely to be beneficial for human health. However, administrated polyphenols are extensively metabolized in the digestive […]

Epigenetic effects of green tea polyphenols in cancer.

Epigenetic effects of green tea polyphenols in cancer. Epigenomics. 2013 Dec;5(6):729-41 Authors: Henning SM, Wang P, Carpenter CL, Heber D Abstract Epigenetics describes heritable alterations of gene expression and chromatin organization without changes in DNA sequence. Both hypermethylation and hypomethylation of DNA can affect gene expression and the multistep process of carcinogenesis. Epigenetic changes are […]

Management of cardiorenal metabolic syndrome in diabetes mellitus: a phytotherapeutic perspective.

Management of cardiorenal metabolic syndrome in diabetes mellitus: a phytotherapeutic perspective. J Diabetes Res. 2014;2014:313718 Authors: Song MK, Davies NM, Roufogalis BD, Huang TH Abstract Cardiorenal syndrome (CRS) is a complex disease in which the heart and kidney are simultaneously affected and their deleterious declining functions are reinforced in a feedback cycle, with an accelerated […]

Potential antineoplastic effects of Aloe-emodin: a comprehensive review.

Potential antineoplastic effects of Aloe-emodin: a comprehensive review. Am J Chin Med. 2014;42(2):275-88 Authors: Chen R, Zhang J, Hu Y, Wang S, Chen M, Wang Y Abstract Aloe-emodin (AE), a bioactive anthraquinone derived from both Aloe vera and Rheum officinale, has recently been demonstrated to have various pharmacological activities. With the widespread popularity of natural […]

An overview of important ethnomedicinal herbs of Phyllanthus species: present status and future prospects.

An overview of important ethnomedicinal herbs of Phyllanthus species: present status and future prospects. ScientificWorldJournal. 2014;2014:839172 Authors: Sarin B, Verma N, Martín JP, Mohanty A Abstract The genus Phyllanthus consists of more than 1000 species, of which many are used as traditional medicines. The plant extracts have been used since ancient times, for treating hypertension, […]

Structure-activity association of flavonoids in lung diseases.

Structure-activity association of flavonoids in lung diseases. Molecules. 2014;19(3):3570-95 Authors: Lago JH, Toledo-Arruda AC, Mernak M, Barrosa KH, Martins MA, Tibério IF, Prado CM Abstract Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have […]

A double-blind, randomized study to assess the validity of applied kinesiology (AK) as a diagnostic tool and as a nonlocal proximity effect.

A double-blind, randomized study to assess the validity of applied kinesiology (AK) as a diagnostic tool and as a nonlocal proximity effect. Explore (NY). 2014 Mar-Apr;10(2):99-108 Authors: Schwartz SA, Utts J, Spottiswoode SJ, Shade CW, Tully L, Morris WF, Nachman G Abstract PREMISE: Applied Kinesiology (AK) is a diagnostic technique widely used within the Integrative […]

Use of natural compounds in the management of diabetic peripheral neuropathy.

Use of natural compounds in the management of diabetic peripheral neuropathy. Molecules. 2014;19(3):2877-95 Authors: Galuppo M, Giacoppo S, Bramanti P, Mazzon E Abstract Nephropathy, retinopathy cardiomyopathy and peripheral neuropathy are all recognized as important complications in about 50% of diabetes mellitus (DM) patients, mostly related to a poor glycemic control or to an improper management […]

Metabolism of flavonoids in human: a comprehensive review.

Metabolism of flavonoids in human: a comprehensive review. Curr Drug Metab. 2014 Jan;15(1):48-61 Authors: Chen Z, Zheng S, Li L, Jiang H Abstract Flavonoids are naturally occurring polyphenols, which are widely taken in diets, supplements and herbal medicines. Epidemiological studies have shown a flavonoid-rich diet is associated with the decrease in incidence of a range […]

Antibacterial properties studies of trunk barks of Terminalia ivorensis (Combretaceae), a commercial and medicinal specie, on some methicillin-resistant Staphylococci spp strains.

Antibacterial properties studies of trunk barks of Terminalia ivorensis (Combretaceae), a commercial and medicinal specie, on some methicillin-resistant Staphylococci spp strains. Afr Health Sci. 2014 Sep;14(3):753-6 Authors: Coulibaly K, Zirihi GN, Guessennd-Kouadio N, Oussou KR, Dosso M Abstract BACKGROUND: Methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and coagulase-negative Staphylococcus infections are a worldwide concern. Terminalia ivorensis, of […]

Green Tea Consumption and Risk of Pancreatic Cancer: A Meta-analysis.

Green Tea Consumption and Risk of Pancreatic Cancer: A Meta-analysis. Nutrients. 2014;6(11):4640-4650 Authors: Zeng JL, Li ZH, Wang ZC, Zhang HL Abstract Emerging laboratory and animal studies indicate that green tea inhibits development and progression of pancreatic cancer, but evidence from epidemiologic studies appears inconsistent and inconclusive. A meta-analysis summarizing published case-control and cohort studies […]

The effect of back massage on blood pressure in the patients with primary hypertension in 2012-2013: a randomized clinical trial.

The effect of back massage on blood pressure in the patients with primary hypertension in 2012-2013: a randomized clinical trial. Int J Community Based Nurs Midwifery. 2014 Oct;2(4):251-8 Authors: Mohebbi Z, Moghadasi M, Homayouni K, Nikou MH Abstract BACKGROUND: Tension and stress are among the factors that lead to hypertension. In most individuals, behavioral strategies, […]

The Effect of Omega-3 Fatty Acid Supplementation on Maternal Depression during Pregnancy: A Double Blind Randomized Controlled Clinical Trial.

The Effect of Omega-3 Fatty Acid Supplementation on Maternal Depression during Pregnancy: A Double Blind Randomized Controlled Clinical Trial. Int J Community Based Nurs Midwifery. 2014 Jul;2(3):142-7 Authors: Kaviani M, Saniee L, Azima S, Sharif F, Sayadi M Abstract BACKGROUND: Depression is one of the most debilitating disorders during pregnancy and its recovery and treatment […]

The effect of massage therapy by patients’ companions on severity of pain in the patients undergoing post coronary artery bypass graft surgery: a single-blind randomized clinical trial.

The effect of massage therapy by patients’ companions on severity of pain in the patients undergoing post coronary artery bypass graft surgery: a single-blind randomized clinical trial. Int J Community Based Nurs Midwifery. 2014 Jul;2(3):128-35 Authors: Najafi SS, Rast F, Momennasab M, Ghazinoor M, Dehghanrad F, Mousavizadeh SA Abstract BACKGROUND: Pain on mid sternotomy incision […]