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The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial.

Viola odorata

The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial. J Evid Based Complementary Altern Med. 2015 May 6; Authors: Qasemzadeh MJ, Sharifi H, Hamedanian M, Gharehbeglou M, Heydari M, Sardari M, Akhlaghdoust M, Minae MB Abstract This study aimed to investigate the effect of violet syrup on cough alleviation in children with intermittent asthma. In a parallel, double-blind, randomized controlled trial, 182 children aged 2 to 12 years with intermittent asthma were randomly assigned 1:1 to receive violet syrup or placebo along with the common standard treatments in both groups (short-acting β-agonist). Both groups were evaluated in terms of the duration until cough suppression was achieved. No significant difference was observed in basic characteristics. The duration lasting to yield more than 50% cough reduction and 100% cough suppression was significantly […] – Read More



Antitumor Phenylpropanoids Found in Essential Oils.

Essential Oils

Antitumor Phenylpropanoids Found in Essential Oils. Biomed Res Int. 2015;2015:392674 Authors: Carvalho AA, Andrade LN, de Sousa ÉB, de Sousa DP Abstract The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high-priorities in the research effort toward more effective treatments for cancer. The phenylpropanoids are natural products found in many aromatic and medicinal plants, food, and essential oils. They exhibit various pharmacological activities and have applications in the pharmaceutical industry. In this review, the anticancer potential of 17 phenylpropanoids and derivatives from essential oils is discussed. Chemical structures, experimental report, and mechanisms of action of bioactive substances are presented. PMID: 25949996 [PubMed – as supplied by publisher]



Cancer therapy with phytochemicals: evidence from clinical studies.

Viscum album (European Mistletoe)

Cancer therapy with phytochemicals: evidence from clinical studies. Avicenna J Phytomed. 2015 Mar-Apr;5(2):84-97 Authors: Hosseini A, Ghorbani A Abstract Cancer is still one of the major causes of mortality in both developing and developed countries. At present, in spite of intensive interventions, a large number of patients suffer from poor prognosis. Therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has been continued. According to the traditional recommendations and experimental studies, numerous medicinal plants have been reported to have anticancer effect. Also antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects of several phytochemicals have been shown in in vitro experiments or animal studies. However, only a small number have been tested in cancerous patients and limited evidence exists for their clinical effectiveness. Also, regarding some phytochemicals, only beneficial effects on cancer-related symptoms or on quality of […] – Read More



Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.

Liver Fibrosis

Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response. Int J Inflam. 2015;2015:943497 Authors: Duval F, Moreno-Cuevas JE, González-Garza MT, Maldonado-Bernal C, Cruz-Vega DE Abstract Inflammation is a central feature of liver fibrosis as suggested by its role in the activation of hepatic stellate cells leading to extracellular matrix deposition. During liver injury, inflammatory cells are recruited in the injurious site through chemokines attraction. Thus, inflammation could be a target to reduce liver fibrosis. The pandemic trend of obesity, combined with the high incidence of alcohol intake and viral hepatitis infections, highlights the urgent need to find accessible antifibrotic therapies. Medicinal plants are achieving popularity as antifibrotic agents, supported by their safety, cost-effectiveness, and versatility. The aim of this review is to describe the role of inflammation and the immune response in […] – Read More



Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma.

Ivy Leaves (Hedera helix)

Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma. Phytomedicine. 2014 Sep 15;21(10):1216-20 Authors: Zeil S, Schwanebeck U, Vogelberg C Abstract Ivy leaves dry extract is registered as an expectorant in patients with respiratory diseases associated with productive cough. Next to its secretolytical properties, bronchospasmolytical effects are described. However only limited data exist about a possible therapeutical effect in asthmatic patients. In this double blind, placebo-controlled, randomized cross-over study, 30 children (median age 9.07 years (min-max: 6-11)) suffering from partial or uncontrolled mild persistent allergic asthma despite long-term treatment with 400 μg budesonide equivalent were investigated. After a four week run-in period, patients either received ivy leaves dry extract for four weeks in addition to their inhaled corticosteroid therapy or placebo, followed by a wash-out […] – Read More



Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients.

Glycyrrhiza glabra

Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. Fitoterapia. 2014 Sep;97:1-14 Authors: Ajazuddin, Alexander A, Qureshi A, Kumari L, Vaishnav P, Sharma M, Saraf S, Saraf S Abstract The current review emphasizes on the herbal bioenhancers which themselves do not possess inherent pharmacological activity of their own but when co-administered with Active Pharmaceutical Ingredients (API), enhances their bioavailability and efficacy. Herbal bioenhancers play a crucial role in enhancing the bioavailability and bioefficacy of different classes of drugs, such as antihypertensives, anticancer, antiviral, antitubercular and antifungal drugs at low doses. This paper highlights various natural compounds that can be utilized as an efficient bioenhancer. Several herbal compounds including piperine, quercetin, genistein, naringin, sinomenine, curcumin, and glycyrrhizin have demonstrated capability to improve the pharmacokinetic parameters of several potent API. This article also focuses on various United States […] – Read More



Ginkgo biloba extract for essential hypertension: a systemic review.

Ginkgo biloba

Ginkgo biloba extract for essential hypertension: a systemic review. Phytomedicine. 2014 Sep 15;21(10):1131-6 Authors: Xiong XJ, Liu W, Yang XC, Feng B, Zhang YQ, Li SJ, Li XK, Wang J Abstract BACKGROUND: Ginkgo biloba extract (GBE), a traditional natural herbal product, is often used in the treatment of essential hypertension (EH) as complementary therapy in China and European countries. AIM: To critically assess the current clinical evidence of efficacy and safety of GBE for EH. METHODS: 7 electronic databases (Cochrane Library, PubMed, EMBASE, VIP, CBM, Wanfang data, and CNKI) were searched to identify randomized controlled trials (RCTs) of GBE for EH. Methodological quality was assessed independently using the Cochrane Handbook for Systematic Reviews of Interventions. RESULTS: A total of 9 RCTs with 1012 hypertensive patients were identified and reviewed. Most RCTs were of high risk of bias with flawed study […] – Read More



Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level.

Silybum marianum (Milk Thistle)

Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level. Med Chem. 2015 Apr 30; Authors: Rasool M, Malik A, Arooj M, Manan A, Qazi MH, Kamal MA, Sheikh IA, Gan SH, Asif M, Naseer MI Abstract Every year, cancer takes the life of millions of people. Conventional treatments have produced unsatisfactory results for some types of cancer, and the side effects are extensive, leading to a shift in the focus of treatment towards alternative medicines. Indeed, medicinal plants have long been investigated by scientists for their anti-cancer properties. Some phytochemicals that are important active constituents of plants, including catechins, ursolic acid, silymarin, glycyrrhizin, ellagic acid, gallic acid and various types of flavonoids, have shown promise in future cancer management. The current review covers various aspects of cancer treatment based on medicinal […] – Read More



Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications.

Coffea spp (Coffee)

Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications. Nat Prod Commun. 2015 Jan;10(1):187-200 Authors: Chen J, Mangelinckx S, Adams A, Wang ZT, Li WL, De Kimpe N Abstract Diabetes mellitus, together with its various complications, is becoming a serious threat to human health. Natural products are secondary metabolites widely distributed in plants, having a broad range of biological activities. The development of antidiabetic medication from natural products, especially those originating from plants with a traceable folk-usage history in treating diabetes, is receiving more attention. Many studies highlighted not only the benefits of natural flavonoids with hypoglycemic effects, but also their importance in the management of diabetic complications. This review describes selected natural flavonoids that have been validated for their hypoglycemic properties, together with their mechanisms of action. Also discussed are their activities in […] – Read More



Application of microencapsulated essential oils in cosmetic and personal health care products – A Review.

Essential oils

Application of microencapsulated essential oils in cosmetic and personal health care products – A Review. Int J Cosmet Sci. 2015 Apr 29; Authors: Carvalho IT, Estevinho BN, Santos L Abstract Nowadays, the consumers around the world are increasingly focused on health and beauty. The renewed consumer interest in natural cosmetic products create the demand for new products and reformulated others with botanical and functional ingredients. In cosmetic products, essential oils play a major role as fragrance ingredients. They can optimize its proprieties and preservation, as well as the marketing image of the final product. Microencapsulation of essential oils can protect and prevent the loss of volatile aromatic ingredients, improve the controlled release and stability of this core materials. The importance of essential oils for cosmetic industry and its microencapsulation was reviewed in this paper. Also a briefly introduction about the […] – Read More



A Review on Ethnobotanical and Therapeutic Uses of Fenugreek (Trigonella foenum-graceum L).

Trigonella foenum-graecum (Fenugreek)

A Review on Ethnobotanical and Therapeutic Uses of Fenugreek (Trigonella foenum-graceum L). J Evid Based Complementary Altern Med. 2015 Apr 27; Authors: Bahmani M, Shirzad H, Mirhosseini M, Mesripour A, Rafieian-Kopaei M Abstract Fenugreek with the scientific name of Trigonella foenum-graceum L and with leaves consisting of 3 small obovate to oblong leaflets is an annual herbaceous plant of the Fabaceae family. It is native to the eastern Mediterranean but is cultivated worldwide. This plant has medicinal alkaloids, steroid compounds, and sapogenins and many uses have been mentioned for this plant in traditional medicine. This plant has been used to ease childbirth, to aid digestion, and as a general tonic to improve metabolism. Trigonelline is considered as the most important metabolite of fenugreek, which is very effective in treating diabetes and decreasing blood cholesterol. Diaszhenin is another important compound in […] – Read More



Antifertility activity of medicinal plants.

Citrus limonum

Antifertility activity of medicinal plants. J Chin Med Assoc. 2015 Apr 25; Authors: Daniyal M, Akram M Abstract The aim of this review was to provide a comprehensive summary of medicinal plants used as antifertility agents in females throughout the world by various tribes and ethnic groups. We undertook an extensive bibliographic review by analyzing classical text books and peer reviewed papers, and further consulting well accepted worldwide scientific databases. We performed CENTRAL, Embase, and PubMed searches using terms such as “antifertility”, “anti-implantation”, “antiovulation”, and “antispermatogenic” activity of plants. Plants, including their parts and extracts, that have traditionally been used to facilitate antifertility have been considered as antifertility agents. In this paper, various medicinal plants have been reviewed for thorough studies such as Polygonum hydropiper Linn, Citrus limonum, Piper nigrum Linn, Juniperis communis, Achyanthes aspera, Azadirachta indica, Tinospora cordifolia, and […] – Read More



Feverfew for preventing migraine.

Tanacetum parthenium (Feverfew)

Feverfew for preventing migraine. Cochrane Database Syst Rev. 2015 Apr 20;4:CD002286 Authors: Wider B, Pittler MH, Ernst E Abstract BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews on ‘Feverfew for preventing migraine’ (2004, Issue 1). Feverfew (Tanacetum parthenium L.) extract is a herbal remedy, which has been used for preventing attacks of migraine. OBJECTIVES: To systematically review the evidence from double-blind randomised controlled trials (RCTs) assessing the clinical efficacy and safety of feverfew monopreparations versus placebo for preventing migraine. SEARCH METHODS: For this updated version of the review we searched CENTRAL, MEDLINE, EMBASE and AMED to January 2015. We contacted manufacturers of feverfew and checked the bibliographies of identified articles for further trials. SELECTION CRITERIA: We included randomised, placebo-controlled, double-blind trials assessing the efficacy of feverfew monopreparations for preventing migraine […] – Read More



Treatment of acute gout: a systematic review.

Gout

Treatment of acute gout: a systematic review. Semin Arthritis Rheum. 2014 Aug;44(1):31-8 Authors: Khanna PP, Gladue HS, Singh MK, FitzGerald JD, Bae S, Prakash S, Kaldas M, Gogia M, Berrocal V, Townsend W, Terkeltaub R, Khanna D Abstract OBJECTIVE: Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine; however, subjects have multiple comorbidities that limit the use of some conventional therapies. We systematically reviewed the published data on the pharmacologic and non-pharmacologic agents used for the treatment of acute gouty arthritis. METHODS: A systematic search was performed using PubMed and Cochrane database through May 2013. We included only randomized controlled trials (RCTs) that included NSAIDs, corticosteroids, colchicine, adrenocorticotropic hormone (ACTH), interleukin-1 (IL-1) inhibitors, topical ice, or herbal supplements. RESULTS: Thirty articles were selected for systematic review. The results show that NSAIDs and COX-2 inhibitors are effective agents for the […] – Read More



The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms.

Schisandra chinensis

The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia. 2014 Sep;97:224-33 Authors: Chun JN, Cho M, So I, Jeon JH Abstract Schisandra chinensis fruit extract (SCE) has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. Advances in scientific knowledge and analytical technologies provide opportunities for translational research involving S. chinensis; such research may contribute to future drug discovery. To date, emerging experimental evidence supports the therapeutic effects of the SCE or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions. In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. Moreover, we offer novel insight into future challenges […] – Read More



Herbal Medicine Treatment for Drug-Induced Parkinsonism.

Parkinson’s Disease

Herbal Medicine Treatment for Drug-Induced Parkinsonism. J Altern Complement Med. 2015 Apr 20; Authors: Shim YH, Park JY, Choi WW, Min IK, Park SU, Jung WS, Moon SK, Park JM, Ko CN, Cho KH, Cho SY Abstract OBJECTIVES: To evaluate the role of herbal medicine in drug-induced parkinsonism (DIP) and identify an optimal treatment approach. DESIGN: Retrospective review of DIP cases treated with herbal medicine. SETTINGS/LOCATION: The Parkinson’s clinic at Kyung Hee Traditional Korean Medicine Hospital, Korea. PATIENTS: Twenty-one patients whose clinical outcome and offending drug could be identified. OUTCOME MEASURES: Clinical features, treatments, and outcomes and summarized the clinical course and treatment in each case. RESULTS: Twelve patients had levosulpiride-induced parkinsonism and 9 had parkinsonism induced by another drug. The offending drugs were discontinued in all patients, and all patients received herbal medications during treatment. Nine of 12 patients […] – Read More



Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial.

Narcissus

Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial. BMC Complement Altern Med. 2015 Apr 2;15(1):105 Authors: Nishida S, Eguchi E, Ohira T, Kitamura A, Kato YH, Hagihara K, Iso H Abstract BACKGROUND: In Japan, a traditional herbal medicine, Tokishigyakukagoshuyushokyoto (TJ-38), is often used for the treatment of peripheral coldness, which is a common complaint among Japanese women. However, the effects of this herbal medicine have yet to be examined in a randomized controlled trial. In the current study, the effect of TJ-38 on the peripheral blood flow in women experiencing peripheral coldness was investigated using a parallel-group randomized controlled trial. METHODS: Fifty-eight women aged 23 to 79 years with peripheral coldness were randomly divided into the intervention or control group. They were examined using cold bathing tests, physical examinations, and […] – Read More



Recreational drugs: a new health hazard for patients with concomitant chronic liver diseases.

Recreational drugs

Recreational drugs: a new health hazard for patients with concomitant chronic liver diseases. J Gastrointestin Liver Dis. 2014 Mar;23(1):79-84 Authors: Tarantino G, Citro V, Finelli C Abstract Our purpose in this article is to review the effects of recreational drugs, used either on their own but principally combined with alcohol consumption, in determining hepatic injury or influencing the evolution of some chronic diseases of the liver, specifically HCV infection and NAFLD. A deleterious role of daily use of recreational drugs, in particularly cannabis, has been shown to demonstrate clearly a rapid progression of fibrosis and steatosis, leading to a major severity in patients with chronic hepatitis C. On the other hand, the effects of the misuse of these substances on NAFLD, the main obesity-related comorbidity, leading to addiction, is still to be elucidated even though some clues to the recreational […] – Read More



A review of the medicinal uses, phytochemistry and pharmacology of the genus Sapium.

Sapium glandulosum

A review of the medicinal uses, phytochemistry and pharmacology of the genus Sapium. J Ethnopharmacol. 2014 Aug 8;155(1):9-20 Authors: Al Muqarrabun LM, Ahmat N, Aris SR Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Several species from the genus Sapium possess a broad range of medicinal properties and they have been used as traditional medicines by indigenous groups in several regions such as Malaysia, Africa, Southern China and Bolivia. Most of the species reported to possess therapeutic effects which are used for the treatment of skin-related diseases such as eczema and dermatitis, but they may also be used for overstrain, lumbago, constipation and hernia. Species of this genus are also used to treat wounds and snake bites. In addition, the saps/latex of Sapium glandulosum, Sapium indicum and Sapium sebiferum have/has toxic effects and are used as bird and fish poisons. This review discusses the current […] – Read More



Complementary and Integrative Therapies for Lower Urinary Tract Diseases.

Lower Urinary Tract Diseases

Complementary and Integrative Therapies for Lower Urinary Tract Diseases. Vet Clin North Am Small Anim Pract. 2015 Mar 30; Authors: Raditic DM Abstract Consumer use of integrative health care is growing, but evidence-based research on its efficacy is limited. Research of veterinary lower urinary tract diseases could be translated to human medicine because veterinary patients are valuable translational models for human urinary tract infection and urolithiasis. An overview of complementary therapies for lower urinary tract disease includes cranberry supplements, mannose, oral probiotics, acupuncture, methionine, herbs, or herbal preparations. Therapies evaluated in dogs and cats, in vitro canine cells, and other relevant species, in vivo and in vitro, are presented for their potential use as integrative therapies for veterinary patients and/or translational research. PMID: 25838155 [PubMed – as supplied by publisher]



A prospective randomized study of the effectiveness of aromatherapy for relief of postoperative nausea and vomiting.

Essential Oils

A prospective randomized study of the effectiveness of aromatherapy for relief of postoperative nausea and vomiting. J Perianesth Nurs. 2014 Feb;29(1):5-11 Authors: Hodge NS, McCarthy MS, Pierce RM Abstract INTRODUCTION: Postoperative nausea and vomiting (PONV) is a major concern for patients having surgery under general anesthesia as it causes subjective distress along with increased complications and delays in discharge from the hospital. Aromatherapy represents a complementary and alternative therapy for the management of PONV. PURPOSE: The objective of this study was to compare the effectiveness of aromatherapy (QueaseEase, Soothing Scents, Inc, Enterprise, AL) versus an unscented inhalant in relieving PONV. METHODS: One hundred twenty-one patients with postoperative nausea were randomized into a treatment group receiving an aromatic inhaler and a control group receiving a placebo inhaler to evaluate the effectiveness of aromatherapy. FINDINGS: Initial and follow-up nausea assessment scores in […] – Read More



Stepping from traditional to integrative medicine: perspectives of Israeli-Arab patients on complementary medicine’s role in cancer care.

Cancer Care

Stepping from traditional to integrative medicine: perspectives of Israeli-Arab patients on complementary medicine’s role in cancer care. Ann Oncol. 2014 Feb;25(2):476-80 Authors: Ben-Arye E, Massalha E, Bar-Sela G, Silbermann M, Agbarya A, Saad B, Lev E, Schiff E Abstract BACKGROUND: Limited research is available on the perspectives of patients with cancer regarding integration of complementary medicine (CM) in conventional supportive cancer care. The purpose of this study was to explore patients’ perspectives concerning CM integration within conventional oncology settings. PATIENTS AND METHODS: A 27-item questionnaire was constructed and administered to a convenient sample of Arab patients receiving cancer care in three oncology centers in northern Israel. RESULTS: Of the 324 respondents (94.7% response rate), 124 of 313 (39.6%) reported the use of CM for cancer-related outcomes. A logistic regression model indicated that CM was used with active chemo- or radiotherapy […] – Read More



Effect of Rosa damascene aromatherapy on sleep quality in cardiac patients: a randomized controlled trial.

Rosa damascena

Effect of Rosa damascene aromatherapy on sleep quality in cardiac patients: a randomized controlled trial. Complement Ther Clin Pract. 2014 Aug;20(3):159-63 Authors: Hajibagheri A, Babaii A, Adib-Hajbaghery M Abstract OBJECTIVE: Sleep disorders are common among patients hospitalized in coronary care unit (CCU). This study aimed to investigate the effect of Rosa damascene aromatherapy on sleep quality of patients hospitalized in CCU. METHODS: In this randomized controlled trial, 60 patients who met the inclusion criteria were conveniently sampled and randomly allocated to the experimental and control groups. Patients in the control group received routine care. In the experimental group, patients received routine care and Rosa damascene aromatherapy for three subsequent nights. In the both groups the sleep quality was assessed using the Pittsburgh Sleep Quality Index. RESULTS: After the study, the mean scores of five domains of Pittsburg Sleep Quality Index […] – Read More



Thymoquinone and its therapeutic potentials.

Nigella sativa

Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015 Mar 27; Authors: Darakhshan S, Pour AB, Colagar AH, Sisakhtnezhad S Abstract Herbal medicine has attracted great attention in the recent years and is increasingly used as alternatives to chemical drugs. Several lines of evidence support the positive impact of medicinal plants in the prevention and cure of a wide range of diseases. Thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa seeds and most properties of Nigella sativa are mainly attributed to TQ. A number of pharmacological actions of TQ have been investigated including anti-oxidant, anti-inflammatory, immunomodulatory, anti-histaminic, anti-microbial and anti-tumor effects. It has also gastroprotective, hepatoprotective, nephroprotective and neuroprotective activities. In addition, positive effects of TQ in cardiovascular disorders, diabetes, reproductive disorders and respiratory ailments, as well as in the treatment of bone complications as […] – Read More



Systematic review of traditional chinese medicine for depression in Parkinson’s disease.

Parkinson’s Disease

Systematic review of traditional chinese medicine for depression in Parkinson’s disease. Am J Chin Med. 2014;42(5):1035-51 Authors: Zhang Y, Wang ZZ, Sun HM, Li P, Li YF, Chen NH Abstract Depression is the most common non-motor symptom of Parkinson’s disease (PD). Recent clinical trials have evaluated the effectiveness of traditional Chinese medicine (TCM) in the treatment of depression in PD (dPD). However, the results are conflicting rather than conclusive. To investigate the effectiveness of TCM for the treatment of dPD, a systematic review was conducted. Literature searches and collections were performed to identify studies addressing the treatment of TCM for dPD. The methodological quality and risk of bias in all studies included were evaluated. Weighted mean difference (WMD) with 95% confidence interval (CI) was used as the effect measure. Finally, a total of 10 studies involving 582 patients were identified. […] – Read More



Lawsonia inermis L. (henna): ethnobotanical, phytochemical and pharmacological aspects.

Lawsonia inermis (Henna)

Lawsonia inermis L. (henna): ethnobotanical, phytochemical and pharmacological aspects. J Ethnopharmacol. 2014 Aug 8;155(1):80-103 Authors: Badoni Semwal R, Semwal DK, Combrinck S, Cartwright-Jones C, Viljoen A Abstract ETHNOPHARMACOLOGICAL RELEVANCE: The use of Lawsonia inermis L. (henna) for medicinal and cosmetic purposes is inextricably linked to ancient and modern cultures of North Africa and Asia. Literature and artwork indicates that Lawsonia inermis played an important holistic role in the daily lives of some ancient cultures, providing psychological and medicinal benefits, as well as being used for personal adornment. Although henna was historically applied to the hands and feet to protect against fungal pathogens and to hair to combat lice and dandruff, other traditional uses include the treatment of liver and digestive disorders, reduction of tissue loss in leprosy, diabetic foot disorders and ulcers. PHYTOCHEMISTRY: Almost 70 phenolic compounds have been isolated […] – Read More



Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum.

Ganoderma lucidum

Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17 Authors: Bhardwaj N, Katyal P, Sharma AK Abstract Acute inflammation is the result of a complex signal transduction pathway that protects and heals our body and is necessary for our good health and normal wellbeing. Whereas, chronic inflammation can be correlated well with the onset of a plethora of autoimmune disorders; rheumatoid arthritis, systemic lupus and polymyalgia, rheumatic and other diseases like asthma, inflammatory bowel diseases, cardiovascular disorders, ulcerative colitis and Crohn’s disease. Also, it has been reported to be associated with the onset of various cancers. An effective anti-inflammatory drug should be able to inhibit the development of chronic inflammation without interfering in normal homeostasis. A number of herbal drugs have been identified in the past that can target inflammatory […] – Read More



Developing therapies for peanut allergy.

Peanut

Developing therapies for peanut allergy. Int Arch Allergy Immunol. 2014;165(3):179-94 Authors: Bublin M, Breiteneder H Abstract: Peanut allergy is an IgE-mediated, persisting immune disorder that is of major concern worldwide. Currently, no routine immunotherapy is available to treat this often severe and sometimes fatal food allergy. Traditional subcutaneous allergen immunotherapy with crude peanut extracts has proven not feasible due to the high risk of severe systemic side effects. The allergen-specific approaches under preclinical and clinical investigation comprise subcutaneous, oral, sublingual and epicutaneous immunotherapy with whole-peanut extracts as well as applications of hypoallergenic peanut allergens or T cell epitope peptides. Allergen-nonspecific approaches include monoclonal anti-IgE antibodies, TCM herbal formulations and Toll-like receptor 9-based immunotherapy. The potential of genetically engineered plants with reduced allergen levels is being explored as well as the beneficial influence of lactic acid bacteria and soybean isoflavones on peanut […] – Read More



The effectiveness of essential oils for patients with neck pain: a randomized controlled study.

Essential Oils

The effectiveness of essential oils for patients with neck pain: a randomized controlled study. J Altern Complement Med. 2014 Oct;20(10):771-9 Authors: Ou MC, Lee YF, Li CC, Wu SK Abstract OBJECTIVES: To assess the efficacy of aromatic essential oils on neck pain. DESIGN: Sixty participants with a history of neck pain and Neck Disability Index (NDI) score >10% were selected and randomly divided into control and experimental groups. SETTING: Motion analysis laboratory at Hungkuang University. INTERVENTION: For the experimental group, the intervention included 3% concentration cream composed of four essential oils: marjoram, black pepper, lavender, and peppermint. For the control group, only an unscented cream was provided. For 4 weeks, all patients applied 2 g cream directly to the affected area daily after showering or bathing. OUTCOME MEASURES: Assessment was performed by using a visual analogue scale (VAS), NDI, pressure pain […] – Read More



Alternative approach for mitigation of doxorubicin-induced cardiotoxicity using herbal agents.

Cardiotoxicity

Alternative approach for mitigation of doxorubicin-induced cardiotoxicity using herbal agents. Curr Clin Pharmacol. 2014;9(3):288-97 Authors: Khan MA, Singh M, Khan MS, Ahmad W, Najmi AK, Ahmad S Abstract Doxorubicin (DOX) is an effective and frequently used chemotherapeutic agent for various malignancies. However, its clinical use is hampered due to the development of cardiotoxicity. Investigations have proved that DOX-induced cardiotoxicity occurs through mechanisms other than those mediating its antitumor effect. This theory sheds light on the development of strategies for cardioprotection without altering therapeutic effectiveness of DOX. Bioactive plant constituents of dietary supplements, traditional herbs and foods with potential health benefits can play an important role in therapeutics. This manuscript is an exhaustive review and prospect of herbal and botanical agents against DOX-induced cardiotoxicity with their proposed mechanisms. The activity of herbs evaluated against DOX-induced cardiotoxicity has shown number of mechanisms […] – Read More