Antidepressant-like effects and mechanisms of flavonoids and related analogues.

Antidepressant-like effects and mechanisms of flavonoids and related analogues.

Eur J Med Chem. 2016 May 12;121:47-57

Authors: Guan LP, Liu BY

Abstract

Flavonoids, possessing a basic phenylbenzopyrone core, are important components of the human diet, and are found in many medicinal plants. Flavonoids include chalcones, flavanones and their derivatives. Synthetic and natural isolated flavonoids display an enormous number of biological activities such as antitumor, antiplatelet, anti-malarial, anti-inflammatory, antidepressant and anticonvulsant properties. This review article focuses on the antidepressant-like effect, structure-activity relationship and mechanism of action of total flavonoid extracts isolation from natural sources, flavonoid compounds and their related analogues.

PMID: 27214511 [PubMed – as supplied by publisher]