[Advances in studies on pharmacokinetics of aristolochic acid I]

[Advances in studies on pharmacokinetics of aristolochic acid I]: Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(19):1573-5 Authors: Wang G, Wang ZM, Sun QS

Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera.

PMID: 17165576 [PubMed - indexed for MEDLINE]